IMMUNE-PHARMACOLOGY-PART-II

ANTINEOPLASTIC DRUGS -Continues...

In this post, we deal with drugs used in therapeutics of cancerous or malignant neoplastic diseases only as noncancerous neoplasms are not life-threatening.

In addition to chemotherapy cancerous cells are removed or destroyed by surgery, immunotherapy, and radiotherapy. These are often used as an adjuvant initial therapies to reduce the neoplastic burden.in all cases chemotherapy must follow as final and end-stage treatment.

Classifications

1.Alkylating Agents:-

a)Nitrogen Mustard Compounds

1.Mechlorethamine

2.Cyclophosphamide

3.Ifosfamide

4.Melphalan

5.Chlorambucil

b)Nitrosoureas

1.Carmustine

2.Lomustine

3.Semustine

4.Streptozocin

Platinum Compounds

1.Cisplatin

2.Carboplatin

Alkyl Sulphones

1.Busulfan

Triazenes

1.Dacarbazine(DTIC)

Antibiotics

1.Dactinomycin

2.Doxorubicin

3.Daunorubicin

4.Bleomycin

5.Mitomycin

6.Plicamycin

Antimetabolites

1.Methotrexate-A folic acid analog

2.Pyrimidine Analogues:-

(i)Fluorouracil -5-Fluorouracil;5FU

(ii)Floxuridine-Fluorodeoxyuridine-FUdR

(iii)Cytarabine-Cytosine arabinoside

3.Purines:-

(i)6-mercaptopurine

(ii)Thioguanine (TG)

(iii)Pentostatin

Natural Products  

1.Vinca Alkaloids:-

(i)Vinblastin (VLB)

(ii)Vincristine

2.Epipodophyllotoxins:-

(i) Etoposide

(ii) Teniposide

3.Enzymes:-

(i) L-Asparaginase

Biological Response Modifiers

Interferon-alfa

Hormones 

1.Adrenocorticosteroids:-

(i) Prednisone

2.Progestins

(i) Hydroxyprogesterone

(ii) Medroxyprogesterone

(iii) Megestrol Acetate

3.Estrogen:-

(i) Diethylstilbesterol

(ii) Ethynylestradiol

4.Antiestrogen:-

Tamoxifen

5.Androgens:-

(i) Testosterone propionate

(ii) Fluoxymesterone

6.Antiandrogen:-

Flutamide

7.Gonadotropin-Releasing Hormone-Analogue:-

Leuprolide