IMMUNE-PHARMACOLOGY-PART-IX-ANTIBIOTICS-Contd..

ANTIBIOTICS-ANTICANCER-Continue...

4.Mitomycin:-

This drug belongs to the family of aziridine antibiotic isolated from Streptomyces caespitosus or S.lavendulae.

Mechanism:-

After taken by the intravenous route(Recommended) through metabolism the drug is reduced to an alkylating agent by damaging the DNA strand by alkylation and kill the cell.

Clinical Uses:-

1.Cervical carcinoma

2. Lung cancer

3.Bladder and colon cancer.

5.Pilcamycin:-

This is an antibiotic extracted from Streptomyces plicatus.

Mechanism:-

It impairs the DNA base pairs in a manner similar to dactinomycin and inhibits RNA synthesis.

This drug can be taken intravenously.

Clinical Use:-

1.Testicular cancer(very limited use because of severe toxicity)

2.Malignant hypercalcemia.

Toxicity:-

1.Bone marrow suppression

2.Bleeding disorders

3.Liver damage

4.Kidney failure.