PHENCYCLIDINE
Phencyclidine is a drug of abuse that produces dissociative anesthesia (a condition that composed of analgesia and catatonia without loss of consciousness). It is a ketamine analog. Commercially it is known as PCP or Angel's Dust.
It is frequently used as a veterinary anesthetic agent.
After the introduction of Ketamin by Parke-Davis which is more tolerable than PCP, this drug is withdrawn from the medical field because of its high dissociative hallucinogenic effects.
Mechanism
Its action is by blocking the excitatory receptors of N-Methyl-D-Aspartate (NMDA) and glutamate and thereby inhibiting the serotonin uptake and thereby producing depression and analgesia anesthesia with catatonia(difficult to roll or turn the head) without loss of consciousness.
CNS Effects
Schizophrenia-like psychosis involving distortion of time, space, and image.
At toxic doses, it produces seizures and coma.
Peripheral Effects
1.Increased heart rate
2.Hypertension
3.Ataxia
4.Increased salivary secretion
5.Nystagmus(involuntary and irregular eyeball movements)
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