MARIJUANA
Marijuana botanically known as Cannabis Indica and Cannabis Sativa is a famous drug of abuse. In India, it is familiar with the name Ganja or Hashish. It is tobacco-like stuff that is smoked like a cigar. The smoke which is inhaled contains the active ingredient Cannabinol an alkaloid that causes all its effects.
Chemistry
Marijuana is available in two main strains as C.Indica and C.Sativa and a variety of hybrids by crossing these two strains in various percentages.
Marijuana contains different chemical forms of cannabinol as 9-Delta Tetra Hydro Cannabinol(THC); Cannabinol(CBN); and Cannabidiol(CBD). Each ingredient has different specific pharmacological effects.
CBN and CBD are specifically acting on our bodies as muscle relaxants. Produce tiredness. Withdrawal symptoms.
THC is specifically acting on the cerebrum, the big brain as a stimulant, enthusiastic, and energetic.
C. Indica is more concentrated with CBD and CBN whereas C.Sativa is more concentrated with THC.
The alkaloids are concentrated in the resins of the plant.
As C.Indica is producing more sedation and tiredness it is used mostly at bedtime whereas the C.Sativa is causing stimulation and exhilaration it is used mostly in the daytime.
General CNS Effects
1.Sedation
2.Euphoria
3.Decreased psychomotor activities
4.Impaired memory and time sense
Physiological Effects
Hypertension
Increased Heart Rate
Dry mouth(Anticholinergic effects)
Bronchodilation
Increased Appetite
Clinical Indications
Dronabinol a pharmaceutical analog of THC is used to treat,
1.Anorexia (Decreased Appetite)
2.Antiemetic.
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